Recommendation ID
What is the clinical effectiveness and rate of adverse events of statin therapy using atorvastatin 20 mg per day compared with atorvastatin 40 mg per day and atorvastatin 80 mg per day in people without established CVD?
Any explanatory notes
(if applicable)
Why this is important: This guideline has established that atorvastatin 20 mg is clinically and cost effective for the primary prevention of CVD and should be recommended for those at 10% risk of cardiovascular events as assessed using the QRISK2 calculator. However, this analysis looked at the effectiveness of treatment shown by 'high-intensity' statins as a group, as it was not possible to establish the relative effectiveness of atorvastatin 20 mg, 40 mg and 80 mg using trial data. Trial data with clinical outcomes exists for atorvastatin 80 mg against atorvastatin 10 mg only. The rates of adverse events resulting from different doses of atorvastatin in routine clinical practice are also uncertain and would need to be considered in combination with effectiveness in assessing the relative costs and benefits of different doses of atorvastatin.

Source guidance details

Comes from guidance
Cardiovascular disease: risk assessment and reduction, including lipid modification
Date issued
July 2014

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 07/10/2014