- Recommendation ID
Morphine compared with ketamine for first-line management of pain:- Is morphine clinically and cost effective compared with ketamine for first-line pharmacological pain management (in both pre-hospital and hospital settings) in patients with major trauma?
- Any explanatory notes
Why this is important:- The use of opioids as first-line analgesics after major trauma is well established but has been associated with negative side effects. Consequently, intravenous ketamine in sub-anaesthetic doses is often used for analgesia in pre-hospital and hospital settings. Some studies have suggested that intravenous morphine in combination with ketamine provides more effective analgesia than morphine alone. However, there is little evidence from well-controlled trials that directly compares the effectiveness and side effects of morphine and ketamine.
Source guidance details
- Comes from guidance
- Major trauma: assessment and initial management
- Date issued
- February 2016
|Is this a recommendation for the use of a technology only in the context of research?||No|
|Is it a recommendation that suggests collection of data or the establishment of a register?||No|