Advice
Evidence review: economic issues
Cost effectiveness
No cost-effectiveness studies of oral glycopyrronium bromide for use in hyperhidrosis were identified.
Cost
The NHS Electronic Drug Tariff (May 2013) lists the following prices for glycopyrronium bromide oral solution or suspension in Part VIIIB, Arrangements for payment for specials and imported unlicensed medicines:
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glycopyrronium bromide 1 mg/5 ml oral solution/suspension: £150.92 for minimal volume of 100 ml plus £0.01 for each extra ml
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glycopyrronium bromide 2 mg/5 ml oral solution: £262.61 for minimal volume of 100 ml plus £0.14 for each extra ml
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glycopyrronium bromide 2 mg/5 ml oral suspension: £197.59 for minimal volume of 100 ml plus £0.15 for each extra ml.
No price is listed for glycopyrronium bromide oral tablets, and the cost of these will differ depending on the source. NHS Prescription Cost Analysis for England 2012 reported that various glycopyrronium bromide tablets cost between £268.57 and £712.34 per item (the number of tablets per item is not known).
Current drug usage
NHS Prescription Cost Analysis for England 2012 reported that the following items were dispensed, inclusive of items that were imported in 2012:
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Glycopyrronium bromide 200 micrograms/5 ml liquid special: 400 items at a net cost of £138,200.
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Glycopyrronium bromide 500 micrograms /5 ml liquid special: 300 items at a net cost of £112,000.
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Glycopyrronium bromide 2 mg/5 ml liquid special: 800 items at a net cost of £212,100.
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Glycopyrronium bromide 5 mg/5 ml liquid special: 700 items at a net cost of £196,900.
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Glycopyrronium bromide 1 mg/5 ml oral solution: 5800 items at a net cost of £966,000.
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Glycopyrronium bromide 1 mg/5 ml oral suspension: 1000 items at a net cost of £164,400.
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Glycopyrronium bromide 1 mg tablets: 8300 items at net cost of £2,239,400.
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Glycopyrronium bromide 2 mg tablets: 3500 items at a net cost of £1,199,900.
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Robinul 1 mg tablets (import): 500 items at a net cost of £314,400.
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Robinul Forte 2 mg tablets (import): 200 items at a net cost of £136,100.
The total number of items dispensed for oral glycopyrronium bromide was 21,600 at a net cost of £5,732,400. It is not known for which indications these items were prescribed.
No data were identified on the extent of oral use of solution for injection in UK clinical practice.