Chronic anal fissure: 0.2% topical glyceryl trinitrate ointment

(Rectiv or Rectogesic or Glyceryl trinitrate or glyceryltrinitrate).tw. (2121)

(Topical adj3 nitroglycerin).tw. (144)

(topical adj3 nitric oxide).tw. (31)

Nitroglycerin/ (11424)

1 or 2 or 3 or 4 (12141)

Fissure in Ano/ (1839)

(anal adj3 fissure?).tw. (1224)

(ano adj3 fissure?).tw. (163)

6 or 7 or 8 (2183)

5 and 9 (215)

limit 10 to english language (193)

exp review/ (1773989)

(scisearch or psychinfo or psycinfo or medlars or embase or psychlit or psyclit or cinahl or pubmed or medline).ti,ab,sh. (71599)

((hand adj2 search$) or (manual$ adj2 search$)).ti,ab,sh. (6273)

((electronic or bibliographic or computeri?ed or online) adj4 database$).ti,ab. (14011)

(pooling or pooled or mantel haenszel).ti,ab,sh. (46325)

(peto or dersimonian or der simonian or fixed effect).ti,ab,sh. (2738)

or/13-17 (122776)

12 and 18 (55479)

Meta Analysis/ (38678)

(meta-analys$ or meta analys$ or metaanalys$).ti,ab,sh. (67568)

((systematic$ or quantitativ$ or methodologic$) adj5 (review$ or overview$ or synthesis$)).ti,ab,sh. (53736)

(integrative research review$ or research integration).ti,ab,sh. (83)

or/20-23 (104679)

19 or 24 (132915)

clinical trials, phase iv/ or clinical trials, phase iii/ or randomized controlled trials/ or multicenter studies/ (242591)

(random$ or placebo$ or ((singl$ or double$ or triple$ or treble$) and (blind$ or mask$))).ti,ab,sh. (879710)

26 or 27 (977688)

(animal$ not human$).sh. (3735670)

28 not 29 (872591)

25 or 30 (955847)

11 and 31 (90)

11 and (cost$ or economic$).tw.

(Rectiv or Rectogesic or Glyceryl trinitrate or glyceryltrinitrate).tw. (2144)

(Topical adj3 nitroglycerin).tw. (144)

(topical adj3 nitric oxide).tw. (37)

glyceryl trinitrate/ (23129)

1 or 2 or 3 or 4 (23459)

Fissure in Ano/ (1971)

(anal adj3 fissure?).tw. (1407)

(ano adj3 fissure?).tw. (121)

6 or 7 or 8 (2145)

5 and 9 (467)

limit 10 to english language (401)

exp review/ (1727013)

(scisearch or psychinfo or psycinfo or medlars or embase or psychlit or psyclit or cinahl or pubmed or medline).ti,ab,sh. (87309)

((hand adj2 search$) or (manual$ adj2 search$)).ti,ab,sh. (7260)

((electronic or bibliographic or computeri?ed or online) adj4 database$).ti,ab. (17583)

(pooling or pooled or mantel haenszel).ti,ab,sh. (51618)

(peto or dersimonian or der simonian or fixed effect).ti,ab,sh. (3311)

or/13-17 (145092)

12 and 18 (56326)

Meta Analysis/ (67804)

(meta-analys$ or meta analys$ or metaanalys$).ti,ab,sh. (96320)

((systematic$ or quantitativ$ or methodologic$) adj5 (review$ or overview$ or synthesis$)).ti,ab,sh. (90383)

(integrative research review$ or research integration).ti,ab,sh. (88)

or/20-23 (159220)

19 or 24 (186718)

clinical trials, phase iv/ or clinical trials, phase iii/ or randomized controlled trials/ or multicenter studies/ (27736)

(random$ or placebo$ or ((singl$ or double$ or triple$ or treble$) and (blind$ or mask$))).ti,ab,sh. (978983)

26 or 27 (981997)

(animal$ not human$).sh. (2454674)

28 not 29 (886030)

25 or 30 (1004543)

11 and 31 (161)

limit 32 to exclude medline journals (14)

11 and (cost$ or economic$).tw.