Advice

Appendix

Appendix

Search strategy and evidence selection

Search strategy

For the clinical evidence

Embase 1980 to 2015 October 22, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present; searched 22 October 2015

Search strategy 1: Device and Coronary Artery Disease

1. CT.mp.

2. computed tomography.mp.

3. Coronary Artery Disease.mp. or Coronary Artery Disease/

4. Coronary Artery Disease/ or Coronary Disease/ or Coronary Angiography/

5. CAD.mp.

6. myocardial infarction.mp. or Myocardial Infarction/

7. myocardial ischemia.mp. or Myocardial Ischemia/

8. Somatom.mp.

9. Definition.mp.

10. Edge.mp.

11. Siemens.mp.

12. "128".mp.

13. Single source.mp.

14. dual energy.mp.

15. 1 or 2

16. 3 or 4 or 5 or 6 or 7

17. 12 or 13 or 14

18. 8 or 9 or 10 or 11

19. 15 and 16 and 17 and 18

20. limit 19 to english language

21. limit 20 to yr="2011-current"

Search strategy 2: Population and CT

1. CT.tw.

2. computed tomography.tw.

3. Coronary Artery Disease.tw. or Coronary Artery Disease/

4. Coronary Artery Disease/ or Coronary Disease/ or Coronary Angiography/

5. (coronary adj2 disease).tw.

6. CAD.tw.

7. myocardial infarction.tw. or Myocardial Infarction/

8. myocardial ischemia.tw. or Myocardial Ischemia/

9. high heart rate.tw.

10. arrhythmia.tw.

11. (tachycardia or tachyarrhythmia).tw.

12. (obesity or obese).tw.

13. stents.tw.

14. bypass grafts.tw.

15. calcium score.tw.

16. 1 or 2

17. 3 or 4 or 5 or 6

18. 7 or 8 or 9 or 11 or 12 or 13 or 14 or 15

19. 16 and 17 and 18

20. 19 not (perfusion or gene or neuro* or immuno* or simulat* or child* or youth or baby or infant).tw.

21. limit 20 to english language

22. limit 21 to yr="2012-current"

For the economic evidence

Embase 1974 to 2015 Week 43, Ovid MEDLINE(R) 1946 to October Week 4 2015, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations October 28, 20151. CT.mp.

2. computed tomography.mp.

3. Coronary Artery Disease.mp. or Coronary Artery Disease/

4. Coronary Artery Disease/ or Coronary Disease/ or Coronary Angiography/

5. CAD.mp.

6. myocardial infarction.mp. or Myocardial Infarction/

7. myocardial ischemia.mp. or Myocardial Ischemia/

8. Somatom.mp.

9. Definition.mp.

10. Edge.mp.

11. Siemens.mp.

12. "128".mp.

13. Single source.mp.

14. dual energy.mp.

15. 1 or 2

16. 3 or 4 or 5 or 6 or 7

17. 12 or 13 or 14

18. 8 or 9 or 10 or 11

19. 15 and 16 and 17 and 18

20. cost*.mp.

21. economic*.mp.

22. 20 or 21

23. 19 and 22

24. limit 23 to english language

25. limit 24 to yr="2011 -Current"

Cochrane Database of Systematic Reviews: Issue 10 of 12, October 2015

Cochrane Central Register of Controlled Trials: Issue 9 of 12, September 2015

Database of Abstracts of Reviews of Effect: Issue 2 of 4, April 2015

Cochrane Methodology Register: Issue 3 of 4, July 2012

Health Technology Assessment Database: Issue 3 of 4, July 2015

NHS Economic Evaluation Database: Issue 2 of 4, April 2015

1 CT

2 computed tomography

3 Coronary Artery Disease or Coronary Artery Disease

4 Coronary Artery Disease or Coronary Disease or Coronary Angiography

5 CAD

6 myocardial infarction or Myocardial Infarction

7 myocardial ischemia or Myocardial Ischemia

8 Somatom

9 Definition

10 Edge

11 Siemens

12 "128"

13 Single source

14 dual energy

15 #1 or #2

16 #3 or #4 or #5 or #6 or #7

17 #12 or #13 or #14

18 #8 or #9 or #10 or #11

19 #15 and #16 and #17 and #18

20 cost*

21 economic*

22 #20 or #21

23 #19 and #22 Publication Year from 2011 to 2015

Evidence selection

Evidence was selected based on the following criteria:

  • Population: patients with suspected or known CAD with 1 of the following conditions:

    • obesity

    • high levels of coronary calcium (greater than 400 Agatston units [AU])

    • high heart rates (more than 65 beats per minute) that cannot be lowered with drugs

    • arrhythmias (irregular heart rhythm)

    • stents

    • previous bypass grafts.

  • Intervention: Somatom Definition Edge

  • Comparator: ICA, cardiac MRI, SPECT, ECHO

  • Outcomes: diagnostic test accuracy, indeterminacy, radiation exposure and clinical outcomes including side effects associated with the use of contrast medium, major adverse cardiac events, or mortality.

  • Exclusion criteria: duplicates, case studies, editorials, letters, reviews, conference proceedings/abstracts, animal studies, non‑English language studies, studies not using the Somatom Definition Edge.

For the clinical evidence

  • Total number of publications reviewed: 1835

  • Total number of publications considered relevant: 0

  • Total number of publications selected for inclusion in this briefing: 0

For the economic evidence

  • Total abstracts: 90

  • Duplicates: 0

  • Abstracts reviewed: 90

  • Full papers reviewed: 1

  • Exclusion criteria: case studies, editorials, letters, reviews, conference proceedings/abstracts, animal studies, non-English language studies, not using the Somatom Definition Edge

  • Studies for review: 0