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  • Question on Consultation

    Is the proposed process for updating and withdrawing the TAs appropriate to achieve useful and usable guidance?

  • Question on Consultation

    Is the proposed process sufficiently clear? Are further details of the proposed process required by stakeholders?

  • Question on Consultation

    Should NICE consider adapting other elements of the proposed process to achieve more useful and usable guidance?

  • Question on Consultation

    Do you have any other comments on the proposed process for updating the TAs within the proportionate decision-making process?

  • Question on Consultation

    Would it be challenging to implement of any of the recommendations for the updated TAs? Please say why and for whom, and how these could be mitigated.

  • Question on Consultation

    Would implementation of any of the recommendations have significant cost implications?
The content on this page is not current guidance and is only for the purposes of the consultation process.

Review proposal of TA288, TA315, TA336, TA390, TA418, TA572, TA583

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Summary of TAs to be considered for review

A summary of the TAs to be considered for review is listed in Table 1.

Table 1: TAs to be considered for review

TA number

Title

Recommendation

Year of publication

TA288

Dapagliflozin in combination therapy for treating type 2 diabetes

Dapagliflozin in a dual therapy regimen in combination with metformin is recommended as an option for treating type 2 diabetes, only if:

  • a sulfonylurea is contraindicated or not tolerated or

  • the person is at significant risk of hypoglycaemia or its consequences.

Dapagliflozin in combination with insulin with or without other antidiabetic drugs is recommended as an option for treating type 2 diabetes.

2013

TA315

Canagliflozin in combination therapy for treating type 2 diabetes

Canagliflozin in a dual therapy regimen in combination with metformin is recommended as an option for treating type 2 diabetes, only if:

  • a sulfonylurea is contraindicated or not tolerated or

  • the person is at significant risk of hypoglycaemia or its consequences.

Canagliflozin in a triple therapy regimen is recommended as an option for treating type 2 diabetes in combination with:

  • metformin and a sulfonylurea or

  • metformin and a thiazolidinedione.

Canagliflozin in combination with insulin with or without other antidiabetic drugs is recommended as an option for treating type 2 diabetes.

2014

TA336

Empagliflozin in combination therapy for treating type 2 diabetes

Empagliflozin in a dual therapy regimen in combination with metformin is recommended as an option for treating type 2 diabetes, only if:

  • a sulfonylurea is contraindicated or not tolerated, or

  • the person is at significant risk of hypoglycaemia or its consequences.

Empagliflozin in a triple therapy regimen is recommended as an option for treating type 2 diabetes in combination with:

  • metformin and a sulfonylurea or

  • metformin and a thiazolidinedione.

Empagliflozin in combination with insulin with or without other antidiabetic drugs is recommended as an option for treating type 2 diabetes.

2015

TA390 (MTA)

Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetes

Canagliflozin, dapagliflozin and empagliflozin as monotherapies are recommended as options for treating type 2 diabetes in adults for whom metformin is contraindicated or not tolerated and when diet and exercise alone do not provide adequate glycaemic control, only if:

  • a dipeptidyl peptidase‑4 (DPP‑4) inhibitor would otherwise be prescribed and

  • a sulfonylurea or pioglitazone is not appropriate.

2016

TA418

Dapagliflozin in triple therapy for treating type 2 diabetes

Dapagliflozin in a triple therapy regimen is recommended as an option for treating type 2 diabetes in adults, only in combination with metformin and a sulfonylurea.

2016

TA572

Ertugliflozin as monotherapy or with metformin for treating type 2 diabetes

Ertugliflozin as monotherapy is recommended as an option for treating type 2 diabetes in adults for whom metformin is contraindicated or not tolerated and when diet and exercise alone do not provide adequate glycaemic control, only if:

  • a dipeptidyl peptidase 4 (DPP‑4) inhibitor would otherwise be prescribed and

  • a sulfonylurea or pioglitazone is not appropriate.

Ertugliflozin in a dual-therapy regimen in combination with metformin is recommended as an option for treating type 2 diabetes, only if:

  • a sulfonylurea is contraindicated or not tolerated or

  • the person is at significant risk of hypoglycaemia or its consequences.

If patients and their clinicians consider ertugliflozin to be 1 of a range of suitable treatments including canagliflozin, dapagliflozin and empagliflozin, the least expensive should be chosen.

2019

TA583

Ertugliflozin with metformin and a dipeptidyl peptidase-4 inhibitor for treating type 2 diabetes

Ertugliflozin with metformin and a dipeptidyl peptidase‑4 (DPP‑4) inhibitor is recommended as an option for treating type 2 diabetes in adults when diet and exercise alone do not provide adequate glycaemic control, only if:

  • the disease is uncontrolled with metformin and a DPP‑4 inhibitor, and

  • a sulfonylurea or pioglitazone is not appropriate.

If patients and their clinicians consider ertugliflozin to be 1 of a range of suitable treatments, including canagliflozin, dapagliflozin and empagliflozin, the least expensive should be chosen.

2019