Suggested remit: To appraise the clinical and cost effectiveness of norucholic acid within its marketing authorisation for treating primary sclerosing cholangitis.

Status:
Awaiting development
Technology type:
Medicine
Decision:
Selected
Reason for decision:
Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process:
STA Standard
ID number:
6583

Provisional Schedule

Committee meeting:
12 January 2027
Expected publication:
29 April 2027

Project Team

Project lead
Emily Richards

Email enquiries

If you have any queries please email scopingta@nice.org.uk

Stakeholders

Companies sponsors
Dr Falk Pharma (norucholic acid)
Others
Department of Health and Social Care
 
NHS England
Patient carer groups
Addenbrookes Liver Transplant Association
 
Black Health Agency
 
Bladder and Bowel Community
 
Bowel Cancer UK
 
British Liver Trust
 
Colostomy UK
 
Gene People
 
Genetic Alliance UK
 
GUTS UK
 
IA: Ileostomy and Internal Pouch Group
 
IBDrelief
 
Liver4Life
 
LIVErNORTH
 
PSC Support
 
South Asian Health Foundation
 
Specialised Healthcare Alliance
Professional groups
Association of Coloproctology for Great Britain and Ireland
 
Association of Surgeons of Great
 
Britain and Ireland
 
British Association for the Study of the Liver
 
British Geriatrics Society
 
British Liver Nurses Association
 
British Society of Gastroenterology
 
British Transplantation Society
 
NHS Blood and Transplant
 
Primary Care Society for Gastroenterology
 
Royal College of Anaesthetists
 
Royal College of General Practitioners
 
Royal College of Nursing
 
Royal College of Pathologists
 
Royal College of Physicians
 
Royal College of Surgeons
 
Royal Pharmaceutical Society
 
Royal Society of Medicine
 
UK Clinical Pharmacy Association
 
UK-PSC
Associated public health groups
Public Health Wales
 
UK Health Security Agency
Comparator companies
Dr Falk Pharma (ursodeoxycholic acid)
 
Glenmark Pharmaceuticals (ursodeoxycholic acid)
 
Grindecks Kalecks (ursodeoxycholic acid)
 
Strides Pharma (ursodeoxycholic acid)
 
Wockhardt (ursodeoxycholic acid)
General commentators
All Wales Therapeutics and Toxicology Centre
 
Allied Health Professionals Federation
 
Board of Community Health Councils in Wales
 
British National Formulary
 
Care Quality Commission
 
Department of Health - Northern Ireland
 
Healthcare Improvement Scotland
 
Medicines and Healthcare products Regulatory Agency
 
National Association of Primary Care
 
National Pharmacy Association
 
NHS Confederation
 
NHS Wales Joint Commissioning Committee
 
Scottish Medicines Consortium
 
Scottish Society of Gastroenterology
 
Welsh Government
Relevant research groups
Cochrane Hepato-Biliary Group
 
Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders Group
 
Cochrane UK
 
Foundation for Liver Research
 
Genomics England
 
MRC Clinical Trials Unit
 
National Institute for Health Research

Timeline

Key events during the development of the guidance:

Date Update
19 June 2026 Awaiting development. Following on from advice received from the company, timelines for this appraisal are to be confirmed whilst the company confirm their regulatory filing plans. As this appraisal has been referred NICE will continue to monitor any development and will update interested parties if the situation changes.
08 June 2026 Invitation to participate
09 March 2026 - 08 April 2026 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators
09 March 2026 In progress. Scoping commenced.
02 October 2025 Note added to the project documents
15 May 2025 Awaiting development. Status change linked to Topic Selection Decision being set to Selected

For further information on our processes and methods, please see our CHTE processes and methods manual