December 2020: we reviewed our guidance on opioids for non-cancer pain in response to a Public Health England evidence review on dependence on, and withdrawal from, prescribed medicines. We added links in recommendation 1.6.7 to other NICE guidelines and resources that support discussion with patients about opioid prescribing, and safe withdrawal management.
February 2018: We reviewed the evidence on diagnosing peripheral arterial disease in people with diabetes and added new recommendations and recommendations for research. Recommendations are marked as  or .  indicates that the evidence was reviewed and the recommendation added in 2018.  indicates that the evidence was last reviewed in 2012.
Minor changes since publication
April 2022: We added a link to NICE's guideline on medicines associated with dependence or withdrawal symptoms in section 1.6 on management of critical limb ischaemic pain.
October 2021: We added a link to NICE's guideline on shared decision making in recommendation 1.6.7.
October 2018: The antiplatelet therapy link in recommendation 1.2.1 was updated.