Update information

Update information

February 2016: The MHRA has produced a toolkit to ensure female patients are better informed about the risks of taking valproate during pregnancy. Healthcare professionals are advised to use the NICE guideline in conjunction with the latest MHRA advice and resources. Footnotes have been added to the guideline to link to the MHRA's latest advice and resources.

April 2015: Recommendations 1.5.5, 1.5.8 and 1.7.6 have had links to section 1.10 added. Recommendations in section 1.10 related to valproate have been reordered, and a new recommendation on withdrawal of valproate in women of childbearing potential added. These changes are in line with the revised MHRA warning on valproate.

January 2015: The MHRA has strengthened its warnings on the use of valproate in women of childbearing potential.

Minor changes since publication

November 2017: Footnotes for some recommendations were updated with current UK marketing authorisations and Medicines and Healthcare Products Regulatory Agency (MHRA) advice. Links to other guidelines have also been updated. Some research recommendations have been stood down.

ISBN: 978‑1‑4731‑0721‑2

  • National Institute for Health and Care Excellence (NICE)