Procalcitonin testing for diagnosing and monitoring sepsis (ADVIA Centaur BRAHMS PCT assay, BRAHMS PCT Sensitive Kryptor assay, Elecsys BRAHMS PCT assay, LIAISON BRAHMS PCT assay and VIDAS BRAHMS PCT assay)

New evidence has become available that could have a material effect on the recommendations. In March 2026, the NICE Prioritisation Board agreed that updated guidance on the use of procalcitonin tests in sepsis would be valuable. It has confirmed that a review of the topic should be prioritised. So, this guidance will be updated on the use of procalcitonin testing to guide decisions on stopping antibiotics in people with confirmed or highly suspected in sepsis.

Also, the use of procalcitonin to guide decisions on starting antibiotics in people with suspected sepsis will be updated in NICE's guideline on suspected sepsis in people aged 16 years and or over: recognition, assessment and early management, NICE's guideline on suspected sepsis in under 16s: recognition, diagnosis and early management and NICE's guideline on suspected sepsis in pregnant or recently pregnant people: recognition, diagnosis and early management.