To inform the committee, NICE did a rapid review of the published literature on the efficacy and safety of this procedure. This comprised a comprehensive literature search and detailed review of the evidence from 13 sources, which was discussed by the committee. The evidence included 1 systematic review, 2 non-randomised comparative studies, 9 case series and 1 case report, and is presented in table 2 of the overview. Other relevant literature is in the appendix of the overview.
The specialist advisers and the committee considered the key efficacy outcomes to be: device implantation success rate, use of adjuvant devices, angiographic aneurysm occlusion rates, Modified Rankin Scale (mRS) score and quality of life.
The specialist advisers and the committee considered the key safety outcomes to be: intraprocedural rupture of aneurysm, other vascular damage, thromboembolic complications including device embolisation and aneurysm rebleeding.
Eight commentaries from patients who had experience of this procedure were received, which were discussed by the committee.