Documents A list of downloadable documents created during development. Final appraisal determination Final appraisal determination Final appraisal determination document PDF 335.23 KB 12 May 2017 Public committee slides PDF 897.2 KB 12 May 2017 Public committee slides PDF 446.9 KB 12 May 2017 Committee papers PDF 15.49 MB 12 May 2017 Invitation to participate Final matrix PDF 100.83 KB 02 June 2016 Final protocol PDF 350.65 KB 27 June 2016 Final scope PDF 111.82 KB 18 August 2016 NICE's response to comments on the draft scope and provisional matrix PDF 134.17 KB 18 August 2016 Draft scope documents Draft scope (post-referral) PDF 146.98 KB 29 February 2016 Provisional matrix (post-referral) PDF 100.11 KB 29 February 2016