Suggested remit: To appraise the clinical and cost effectiveness of loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies
 
Status In progress
Technology type Medicine
Decision Selected
Process STA Standard
ID number 3943

Project Team

Project lead Louise Jafferally

Email enquiries

External Assessment Group Warwick Evidence, Warwick Medical School, University of Warwick

Stakeholders

Companies sponsors Swedish Orphan Biovitrum (loncastuximab tesirine)
Others Department of Health and Social Care
  NHS England
  Welsh Government
Patient carer groups Blood Cancer UK
  Lymphoma Action
Professional groups Association of Cancer Physicians
  Cancer Research UK
  Royal College of Physicians
  Royal College of Radiologists
Associated public health groups None
Comparator companies Baxter Healthcare (ifosfamide)
  Bristol-Myers Squibb (lenalidomide) (confidentialiy agreement signed, participating)
  Kite pharma (axicabtagene ciloleucel) (confidentiality agreement signed, participating)
  Roche (rituximab, polatuzumab vedotin) (confidentiality agreement signed, participating)
  Accord Healthcare (bendamustine, cisplatin, cytarabine, gemcitabine, carboplatin, etoposide, epirubicin, lenalidomide, oxaliplatin) (confidentiality agreement not signed, not participating)
  Baxter Healthcare (ifosfamide) (confidentiality agreeement not signed, not participating)
  Celltrion (rituximab) (confidentiality agreement not signed, not participating)
  Consilient Health (bendamustine, oxaliplatin) (confidentiality agreement not signed, not participating)
  Dr Reddy’s Laboratories (bendamustine) (confidentiality agreement not signed, not participating)
  Fresenius Kabi (gemcitabine, oxaliplatin) (confidentiality agreement not signed, not participating)
  Hospira UK (cisplatin, cytarabine, gemcitabine, carboplatin) (confidentiality agreement not signed, not participating)
  Incyte biosciences (tafasitamab) (confidentiality agreement not signed, not participating)
  Medac (etoposide, epirubicin, oxaliplatin) (confidentiality agreement not signed, not participating)
  Napp Pharmaceuticals (rituximab) (confidentiality agreement not signed, not participating)
  Neon Healthcare (etoposide) (confidentiality agreement not signed, not participating)
  Pfizer (epirubicin, rituximab, cytarabine, oxaliplatin) (confidentiality agreement not signed, not participating)
  Sandoz (rituximab, lenalidomide, cisplatin) (confidentiality agreement not signed, not participating)
  Seacross Pharmaceuticals (epirubicin, bendamustine, oxaliplatin) (confidentiality agreement not signed, not participating)
  Servier Laboratories (pixantrone) (confidentiality agreement not signed, not participating)
  Stragen UK (lenalidomide) (confidentiality agreement not signed, not participating)
  Sun Pharmaceuticals (gemcitabine, oxaliplatin) (confidentiality agreement not signed, not participating)
  Teva UK (lenalidomide) (confidentiality agreement not signed, not participating)
  Thornton and Ross (lenalidomide) (confidentiality agreement not signed, not participating)
  Torrent pharma (lenalidomide) (confidentiality agreement not signed, not participating)
  Zentiva (bendamustine, lenalidomide) (confidentiality agreement not signed, not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health, Social Services and Public Safety for Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Health Specialised Services Committee
Relevant research groups Institute of Cancer Research

Timeline

Key events during the development of the guidance:

Date Update
14 November 2023 Committee meeting: 2
03 October 2023 - 24 October 2023 Draft guidance
12 September 2023 Committee meeting
13 January 2023 Invitation to participate
21 October 2022 - 18 November 2022 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators
21 October 2022 In progress. Scoping commencing
04 October 2022 As you will be aware, the Department for Health and Social Care has asked NICE to conduct an appraisal of Loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies. Please note that following on from information received from the company, this appraisal has been rescheduled into the work programme. We now anticipate that the appraisal will begin during mid-January 2023 when we will write to you about how you can get involved.

For further information on our processes and methods, please see our CHTE processes and methods manual