3 Committee considerations

3 Committee considerations

The evidence

3.1 To inform the committee, NICE did a rapid review of the published literature on the efficacy and safety of this procedure. This comprised a comprehensive literature search and detailed review of the evidence from 6 sources, which was discussed by the committee. The evidence included 4 systematic reviews, 1 randomised controlled trial and 1 cohort study and is presented in table 2 of the interventional procedures overview. Other relevant literature is in the appendix of the overview.

3.2 The specialist advisers and the committee considered the key efficacy outcomes to be: fracture healing or union, functional outcomes and quality of life.

3.3 The specialist advisers and the committee considered the key safety outcome to be: need for subsequent reoperation.

3.4 Three commentaries from patients who had experience of this procedure were received, which were discussed by the committee.

Committee comments

3.5 The committee was informed that delayed-union and non-union fractures should be properly stabilised before using low-intensity pulsed ultrasound to promote fracture healing.

3.6 The evidence came from a variety of fracture types and different sites.

ISBN: 978-1-4731-3026-5

  • National Institute for Health and Care Excellence (NICE)