People have the right to be involved in discussions and make informed decisions about their care, as described in making decisions about your care.
Making decisions using NICE guidelines explains how we use words to show the strength (or certainty) of our recommendations, and has information about prescribing medicines (including off-label use), professional guidelines, standards and laws (including on consent and mental capacity), and safeguarding.
1.1.1 Offer patients and carers clear, consistent information and advice throughout all stages of their care. This should include the risks of surgical site infections, what is being done to reduce them and how they are managed. For more guidance on providing information to adults and discussing their preferences with them, see the NICE guideline on patient experience in adult NHS services. 
1.1.2 Offer patients and carers information and advice on how to care for their wound after discharge. 
1.1.3 Offer patients and carers information and advice about how to recognise a surgical site infection and who to contact if they are concerned. Use an integrated care pathway for healthcare-associated infections to help communicate this information to both patients and all those involved in their care after discharge. 
1.1.4 Always inform patients after their operation if they have been given antibiotics. 
1.2.1 Advise patients to shower or have a bath (or help patients to shower, bath or bed bath) using soap, either the day before, or on the day of, surgery. 
1.2.2 Consider nasal mupirocin in combination with a chlorhexidine body wash before procedures in which Staphylococcus aureus is a likely cause of a surgical site infection. This should be locally determined and take into account:
the type of procedure
individual patient risk factors
the increased risk of side effects in preterm infants (see recommendation 1.3.8)
the potential impact of infection. 
1.2.3 Maintain surveillance on antimicrobial resistance associated with the use of mupirocin. For information on antimicrobial stewardship programmes, see the NICE guideline on antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. 
To find out why the committee made the 2019 recommendations and how they might affect practice, see the rationale and impact section on nasal decolonisation.
Full details of the evidence and the committee's discussion are in evidence review A: nasal decontamination in the prevention of surgical site infection.
1.2.4 Do not use hair removal routinely to reduce the risk of surgical site infection. 
1.2.5 If hair has to be removed, use electric clippers with a single-use head on the day of surgery. Do not use razors for hair removal, because they increase the risk of surgical site infection. 
1.2.6 Give patients specific theatre wear that is appropriate for the procedure and clinical setting, and that provides easy access to the operative site and areas for placing devices, such as intravenous cannulas. Take into account the patient's comfort and dignity. 
1.2.7 All staff should wear specific non-sterile theatre wear in all areas where operations are undertaken. 
1.2.8 Staff wearing non-sterile theatre wear should keep their movements in and out of the operating area to a minimum. 
1.2.9 Do not use mechanical bowel preparation routinely to reduce the risk of surgical site infection. 
1.2.10 The operating team should remove hand jewellery before operations. 
1.2.11 The operating team should remove artificial nails and nail polish before operations. 
1.2.12 Give antibiotic prophylaxis to patients before:
clean surgery involving the placement of a prosthesis or implant
contaminated surgery. 
For advice on antibiotic prophylaxis before caesarean section, see the section on surgical techniques for caesarean section: timing of antibiotic administration in NICE's guideline on caesarean section. For information on antimicrobial stewardship programmes see the NICE guideline on antimicrobial stewardship: systems and processes for effective antimicrobial medicine use.
1.2.13 Do not use antibiotic prophylaxis routinely for clean non-prosthetic uncomplicated surgery. 
1.2.14 Use the local antibiotic formulary and always take into account the potential adverse effects when choosing specific antibiotics for prophylaxis. 
1.2.15 Consider giving a single dose of antibiotic prophylaxis intravenously on starting anaesthesia. However, give prophylaxis earlier for operations in which a tourniquet is used. 
1.2.16 Before giving antibiotic prophylaxis, take into account the timing and pharmacokinetics (for example, the serum half-life) and necessary infusion time of the antibiotic. Give a repeat dose of antibiotic prophylaxis when the operation is longer than the half-life of the antibiotic given. 
1.2.17 Give antibiotic treatment (in addition to prophylaxis) to patients having surgery on a dirty or infected wound. 
1.2.18 Inform patients before the operation, whenever possible, if they will need antibiotic prophylaxis, and afterwards if they have been given antibiotics during their operation. 
1.3.1 The operating team should wash their hands prior to the first operation on the list using an aqueous antiseptic surgical solution, with a single-use brush or pick for the nails, and ensure that hands and nails are visibly clean. 
1.3.2 Before subsequent operations, hands should be washed using either an alcoholic hand rub or an antiseptic surgical solution. If hands are soiled then they should be washed again with an antiseptic surgical solution. 
1.3.3 Do not use non-iodophor-impregnated incise drapes routinely for surgery as they may increase the risk of surgical site infection. 
1.3.4 If an incise drape is required, use an iodophor-impregnated drape unless the patient has an iodine allergy. 
1.3.5 The operating team should wear sterile gowns in the operating theatre during the operation. 
1.3.6 Consider wearing 2 pairs of sterile gloves when there is a high risk of glove perforation and the consequences of contamination may be serious. 
1.3.7 Prepare the skin at the surgical site immediately before incision using an antiseptic preparation. 
1.3.8 Be aware of the risks of using skin antiseptics in babies, in particular the risk of severe chemical injuries with the use of chlorhexidine (both alcohol-based and aqueous solutions) in preterm babies. 
1.3.9 When deciding which antiseptic skin preparation to use, options may include those in table 1. 
Choice of antiseptic skin preparation
First choice unless contraindicated or the surgical site is next to a mucous membrane
Alcohol-based solution of chlorhexidine
At the time of publication (April 2019), 0.5% chlorhexidine in 70% alcohol solution (Hydrex; Prevase) was licensed for 'preoperative skin disinfection prior to minor surgical procedures' and 2.0% chlorhexidine in 70% alcohol applicators (ChloraPrep) was licensed for 'disinfection of the skin prior to invasive medical procedures'. Some formulations of chlorhexidine in alcohol were off label for this use. See NICE's information on prescribing medicines.
Alternative if the surgical site is next to a mucous membrane
Aqueous solution of chlorhexidine
At the time of publication (April 2019), 4.0% aqueous chlorhexidine (Hibiscrub) was licensed for 'preoperative and postoperative skin antisepsis for patients undergoing elective surgery'; however, relevant instructions were limited to use as a body wash to be used before the person enters the operating theatre. Other formulations of aqueous chlorhexidine were off label for this use. See NICE's information on prescribing medicines.
Alternative if chlorhexidine is contraindicated
Alcohol-based solution of povidone-iodine
At the time of publication (April 2019), 10% povidone-iodine alcoholic solution (Videne alcoholic tincture) was licensed for 'topical application'. 10% povidone-iodine (Betadine Alcoholic solution) was licensed for 'antiseptic skin cleanser for major and minor surgical procedures'. Other formulations of povidone-iodine alcoholic solution were off label for this use. See NICE's information on prescribing medicines.
If both an alcohol-based solution and chlorhexidine are unsuitable
Aqueous solution of povidone-iodine
At the time of publication (April 2019), 7.5% povidone-iodine surgical scrub solution (Videne) was licensed for disinfecting the site of incision prior to elective surgery' and 7.5% povidone-iodine (Betadine surgical scrub) was licensed for 'preoperative preparation of patients' skin'. 10% iodine antiseptic solution (Videne) was licensed for 'disinfection of intact external skin or as a mucosal antiseptic' and 10% povidone-iodine solution (Standardised Betadine antiseptic solution) was licensed for 'preoperative and postoperative antiseptic skin cleanser for major and minor surgical procedures'. Other formulations of povidone-iodine aqueous solution were off label for this use. See NICE's information on prescribing medicines.
1.3.10 If diathermy is to be carried out:
use evaporation to dry antiseptic skin preparations and
avoid pooling of alcohol-based preparations. 
To find out why the committee made the 2019 recommendations and how they might affect practice, see the rationale and impact section on antiseptic skin preparation.
Full details of the evidence and the committee's discussion are in evidence review B: skin antiseptics in the prevention of surgical site infection.
1.3.11 Do not use diathermy for surgical incision to reduce the risk of surgical site infection. 
1.3.12 Maintain patient temperature in line with NICE's guideline on hypothermia: prevention and management in adults having surgery. 
1.3.13 Maintain optimal oxygenation during surgery. In particular, give patients sufficient oxygen during major surgery and in the recovery period to ensure that a haemoglobin saturation of more than 95% is maintained. 
1.3.14 Maintain adequate perfusion during surgery. See additional recommendations on intravenous fluids and cardiac monitoring for adults in NICE's guideline on perioperative care in adults. [2008, amended 2020]
1.3.15 Do not give insulin routinely to patients who do not have diabetes to optimise blood glucose postoperatively as a means of reducing the risk of surgical site infection. See the additional recommendation on blood glucose control for adults in NICE's guideline on perioperative care in adults. [2008, amended 2020]
1.3.16 Do not use wound irrigation to reduce the risk of surgical site infection. 
1.3.17 Do not use intracavity lavage to reduce the risk of surgical site infection. 
1.3.18 Only apply an antiseptic or antibiotic to the wound before closure as part of a clinical research trial. 
1.3.19 Consider using gentamicin-collagen implants in cardiac surgery. 
To find out why the committee made the 2019 recommendations and how they might affect practice, see the rationale and impact section on antiseptics and antibiotics before wound closure.
Full details of the evidence and the committee's discussion are in evidence review C: intraoperative antiseptics and antibiotics before wound closure.
1.3.20 When using sutures, consider using antimicrobial triclosan-coated sutures, especially for paediatric surgery, to reduce the risk of surgical site infection. 
1.3.21 Consider using sutures rather than staples to close the skin after caesarean section to reduce the risk of superficial wound dehiscence.
To find out why the committee made the 2019 recommendations and how they might affect practice, see the rationale and impact section on closure methods.
Full details of the evidence and the committee's discussion are in evidence review D: closure materials and techniques in the prevention of surgical site infection.
1.3.22 Cover surgical incisions with an appropriate interactive dressing at the end of the operation. 
1.4.1 Use an aseptic non-touch technique for changing or removing surgical wound dressings. 
1.4.2 Use sterile saline for wound cleansing up to 48 hours after surgery. 
1.4.3 Advise patients that they may shower safely 48 hours after surgery. 
1.4.4 Use tap water for wound cleansing after 48 hours if the surgical wound has separated or has been surgically opened to drain pus. 
1.4.5 Do not use topical antimicrobial agents for surgical wounds that are healing by primary intention to reduce the risk of surgical site infection. 
1.4.6 Do not use Eusol and gauze, or moist cotton gauze or mercuric antiseptic solutions to manage surgical wounds that are healing by secondary intention. 
1.4.7 Use an appropriate interactive dressing to manage surgical wounds that are healing by secondary intention. 
1.4.8 Ask a tissue viability nurse (or another healthcare professional with tissue viability expertise) for advice on appropriate dressings for the management of surgical wounds that are healing by secondary intention. 
1.4.9 When surgical site infection is suspected by the presence of cellulitis, either by a new infection or an infection caused by treatment failure, give the patient an antibiotic that covers the likely causative organisms. Consider local resistance patterns and the results of microbiological tests in choosing an antibiotic. For information on antimicrobial stewardship programmes see the NICE guideline on antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. 
1.4.10 Do not use Eusol and gauze, or dextranomer or enzymatic treatments for debridement in the management of surgical site infection. 
1.4.11 Use a structured approach to care to improve overall management of surgical wounds. This should include preoperative assessments to identify people with potential wound healing problems. Enhanced education of healthcare workers, patients and carers, and sharing of clinical expertise is needed to support this. 
The process of eradicating or reducing asymptomatic carriage of methicillin-resistant S. aureus (MRSA). This used to be referred to as decontamination.
Occurs when a wound has been sutured after an operation and heals to leave a minimal, cosmetically acceptable scar.
Occurs when a wound is deliberately left open at the end of an operation because of excessive bacterial contamination, particularly by anaerobes or when there is a risk of devitalised tissue, which leads to infection and delayed healing. It may be sutured within a few days (delayed primary closure), or much later when the wound is clean and granulating (secondary closure), or left to complete healing naturally without suturing.
Dressings designed to promote the wound healing process through the creation and maintenance of a local, warm, moist environment underneath the chosen dressing, when left in place for a period indicated through a continuous assessment process.
A surgical wound with local signs and symptoms of infection, for example, heat, redness, pain and swelling, and (in more serious cases) with systemic signs of fever or a raised white blood cell count. Infection in the surgical wound may prevent healing, causing the wound edges to separate, or it may cause an abscess to form in the deeper tissues.
Definitions of the severity of surgical site infections vary and this should be taken into account when comparing reported rates of surgical site infection.
Clean: an incision in which no inflammation is encountered in a surgical procedure, without a break in sterile technique, and during which the respiratory, alimentary or genitourinary tracts are not entered.
Clean-contaminated: an incision through which the respiratory, alimentary, or genitourinary tract is entered under controlled conditions but with no contamination encountered.
Contaminated: an incision undertaken during an operation in which there is a major break in sterile technique or gross spillage from the gastrointestinal tract, or an incision in which acute, non-purulent inflammation is encountered. Open traumatic wounds that are more than 12 to 24 hours old also fall into this category.
Dirty or infected: an incision undertaken during an operation in which the viscera are perforated or when acute inflammation with pus is encountered (for example, emergency surgery for faecal peritonitis), and for traumatic wounds if treatment is delayed, there is faecal contamination, or devitalised tissue is present