Recommendations for research

As part of the 2019 update, the guideline committee made 6 research recommendations on the management of pregnancy with chronic hypertension, pre-eclampsia, fetal monitoring, the use of antihypertensives in breastfeeding and advice and follow‑up. A research recommendation from the 2010 guideline which was superseded by these new research recommendations was deleted, and 3 research recommendations where research was now underway or had been completed were also deleted.

Key recommendations for research

1 Management of chronic hypertension in pregnancy

In women who need treatment for chronic hypertension in pregnancy, what is the effectiveness and safety of antihypertensive agents (compared in head-to-head trials) in improving maternal and perinatal outcomes? [2019]

To find out why the committee made the research recommendation on pre-eclampsia, see rationale and impact.

2 Management of hypertension in pregnancy

In women who need treatment for hypertension in pregnancy, what are the adverse neonatal outcomes associated with maternal use of beta blockers (or mixed alpha-beta blockers)? [2019]

To find out why the committee made these research recommendations on chronic hypertension, see rationale and impact.

3 Management of pre-eclampsia

In which women with pre-eclampsia is inpatient management associated with better outcomes for women and babies? [2019]

To find out why the committee made the research recommendation on pre-eclampsia, see rationale and impact.

4 Antihypertensive treatment during the postnatal period

In women who need treatment for high blood pressure after birth, what is the effectiveness and safety (including in breastfeeding women) of antihypertensive agents in achieving adequate blood pressure control? [2019]

To find out why the committee made the research recommendation on antihypertensive treatment during breastfeeding, see rationale and impact.

5 Fetal monitoring

In women with hypertensive disorders of pregnancy, what is the optimal fetal monitoring strategy to detect small for gestational age infants? [2019]

To find out why the committee made the research recommendation on fetal monitoring, see rationale and impact.

6 Advice and follow-up at transfer to community care

In women who have had hypertension during pregnancy, what interventions reduce the risk of a) recurrent hypertensive disorders of pregnancy, and b) subsequent cardiovascular disease? [2019]

To find out why the committee made the research recommendation on follow‑up after hypertensive disorders of pregnancy, see rationale and impact.

Other recommendations for research (from 2010 guideline)

Haematological and biochemical monitoring in women with gestational hypertension

What is the role of assessing haematological or biochemical parameters at diagnosis of gestational hypertension and during surveillance of gestational hypertension? [2010]

  • National Institute for Health and Care Excellence (NICE)