4 Transplant donors

Donors not known to have COVID‑19

4.1 Advise sibling donors that for at least 4 weeks before donating, they should follow the UK government advice on staying at home and away from others (social distancing).

4.2 Tell donors about the clinical signs and symptoms of COVID‑19, transmission risks and related donation restrictions, because this will inform any decision to self-defer from donating.

4.3 For donors who are self-isolating, have previously self-isolated or have been in close contact with someone with COVID‑19, defer donations by at least 4 weeks from the first day of isolation.

4.4 For cryopreservation donations, test for COVID‑19 at the assessment and again at harvest of stem cells or donor lymphocytes.

4.5 If, in exceptional circumstances, fresh cell donations are needed, test for COVID‑19 at the assessment and again 1 to 2 days before starting conditioning. See recommendation 8.9.

4.6 Tell donors to contact the coordinating registry and the collection centre at which they donated if they develop any illness within 2 weeks after donating.

Donors known or suspected to have COVID‑19

4.7 For donors who test positive for COVID‑19, defer donations by 3 months from when their symptoms resolve.

4.8 If haematopoietic stem cell transplantation (HSCT) is urgent and there are no suitable available donors, assess risk and liaise with the registry. Alternative sources of haematopoietic stem cells, such as HLA mismatched (haplo-identical) family members and cord blood, may be available. Discuss the options with the recipient and make sure they are kept informed of the donor situation.

4.9 Explain to donors with known or suspected COVID‑19 that they should not provide other blood products (including lymphocytes) for at least 3 months from when their symptoms resolve.