Guidance
Update information
April 2022: This guideline updates and replaces NICE guideline CG137 (published January 2012).
Minor changes since publication
December 2023: We updated information about the November 2023 MHRA safety advice on valproate to clarify that the relevant recommendations in this guideline are being reviewed and that updated guidance will be available in early 2024.
December 2022: We added links to new MHRA safety advice on risks associated with valproate for the under 55s.