Guidance
Update information
April 2022: This guideline updates and replaces NICE guideline CG137 (published January 2012).
Minor changes since publication
October 2024: We added links to the Medicines and Healthcare products Regulatory Agency (MHRA) Drug Safety Update on valproate use in men and their partners.
August 2024: We added a link to NICE's guideline on adrenal insufficiency.
June 2024: We added links to the MHRA Drug Safety Update on topiramate use in pregnancy and in women and girls of childbearing potential.
December 2023: We updated information about the November 2023 MHRA safety advice on valproate to clarify that the relevant recommendations in this guideline are being reviewed.
December 2022: We added links to new MHRA safety advice on risks associated with valproate for the under 55s.
ISBN: 978-1-4731-4513-9