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Suspected sepsis in people aged 16 or over: recognition, assessment and early management

  • NICE guideline
  • Reference number: NG253
  • Published:  19 November 2025

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Evidence reviews - November 2025

The following documents contain the evidence that was used to develop the 2025 recommendations:

  • Rapid tests for assessing infection in people with suspected sepsis
  • Clinical and cost effectiveness of rapid antigen tests (RAT) and polymerase chain reaction (PCR) tests for guiding treatment in people with suspected sepsis
  • Indicators of organ hypoperfusion in people with suspected sepsis
  • Intravenous fluids for resuscitation
  • Safety of peripheral administration of vasopressor
  • Sepsis risk factors

This page was last updated: 19 November 2025

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