Suspected sepsis in people aged 16 or over: recognition, assessment and early management

Supporting evidence

• Evidence review

• Evidence reviews - November 2025

• D: Rapid tests for assessing infection in people with suspected sepsis (PDF 691 KB)

  Published:

  19 November 2025

• E: Clinical and cost effectiveness of rapid antigen tests (RAT) and polymerase chain reaction (PCR) tests for guiding treatment in people with suspected sepsis (PDF 457 KB)

  Published:

  19 November 2025

• F: Indicators of organ hypoperfusion in people with suspected sepsis (PDF 854 KB)

  Published:

  19 November 2025

• G: Intravenous fluids for resuscitation (PDF 1.05 MB)

  Published:

  19 November 2025

• H: Safety of peripheral administration of vasopressor (PDF 1.14 MB)

  Published:

  19 November 2025

• I: Sepsis risk factors (PDF 911 KB)

  Published:

  19 November 2025

• Evidence reviews - January 2024

• A: Stratifying risk of severe illness or death from sepsis (PDF 968 KB)

  Published:

  31 January 2024

• B: Managing and treating suspected sepsis in acute hospital settings; antibiotic treatment in people with suspected sepsis (PDF 1002 KB)

  Published:

  31 January 2024

• C: Early management of suspected sepsis (except antibiotic therapy) in the NEWS2 population, in acute hospital settings (PDF 1013 KB)

  Published:

  31 January 2024

• Surveillance report

• 2022 exceptional surveillance on intravenous fluid therapy in children and young people (NICE guidelines NG29, NG51, NG143, CG84, CG102 and NG18)

• Appendix A: NICE guideline recommendations and the evidence underlying them (PDF 334 KB)

  Published:

  21 October 2022

• 2022 exceptional surveillance of sepsis: recognition, diagnosis and early management (NICE guideline NG51)

• 2019 exceptional surveillance of sepsis: recognition, diagnosis and early management (NICE guideline NG51) and acutely ill adults in hospital: recognising and responding to deterioration (NICE guideline CG50)

• Full guidance

• NG51 Full guideline - July 2016

• Full guideline (PDF 9.45 MB)

  Published:

  13 July 2016

• Appendices A to G  (PDF 2.1 MB)

  Published:

  13 July 2016

• Appendix H (PDF 3.86 MB)

  Published:

  13 July 2016

• Appendices I to O (PDF 2.47 MB)

  Published:

  13 July 2016