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Suspected sepsis in under 16s: recognition, diagnosis and early management

  • NICE guideline
  • Reference number: NG254
  • Published:  19 November 2025

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  • Tools and resources
  • Information for the public
  • Evidence
  • History

Evidence

Documents containing the evidence that was used to develop the recommendations.

Supporting evidence

  • Evidence review

  • Evidence reviews - January 2024

  • A: Stratifying risk of severe illness or death from sepsis (PDF 968 KB)

    Published:
    31 January 2024
  • B: Managing and treating suspected sepsis in acute hospital settings; antibiotic treatment in people with suspected sepsis (PDF 1002 KB)

    Published:
    31 January 2024
  • C: Early management of suspected sepsis (except antibiotic therapy) in the NEWS2 population, in acute hospital settings (PDF 1013 KB)

    Published:
    31 January 2024
  • Surveillance report

  • 2022 exceptional surveillance on intravenous fluid therapy in children and young people (NICE guidelines NG29, NG51, NG143, CG84, CG102 and NG18)

  • Appendix A: NICE guideline recommendations and the evidence underlying them (PDF 334 KB)

    Published:
    21 October 2022
  • 2022 exceptional surveillance of sepsis: recognition, diagnosis and early management (NICE guideline NG51)

  • 2019 exceptional surveillance of sepsis: recognition, diagnosis and early management (NICE guideline NG51) and acutely ill adults in hospital: recognising and responding to deterioration (NICE guideline CG50)

  • Full guidance

  • NG51 Full guideline - July 2016

  • Full guideline (PDF 9.45 MB)

    Published:
    13 July 2016
  • Appendices A to G  (PDF 2.1 MB)

    Published:
    13 July 2016
  • Appendix H (PDF 3.86 MB)

    Published:
    13 July 2016
  • Appendices I to O (PDF 2.47 MB)

    Published:
    13 July 2016
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