Topotecan for the treatment of relapsed small-cell lung cancer

Appraisal Committee members

The Appraisal Committee is 1 of NICE's standing advisory committees. Its members are appointed for a 3-year term. A list of the Committee members who took part in the discussions for this appraisal appears below. The Appraisal Committee meets 3 times a month except in December, when there are no meetings. There are 4 Appraisal Committees, each with a chair and vice chair. Each Committee considers its own list of technologies, and ongoing topics are not moved between Committees.

Committee members are asked to declare any interests in the technology to be appraised. If it is considered there is a conflict of interest, the member is excluded from participating further in that appraisal.

The minutes of each Appraisal Committee meeting, which include the names of the members who attended and their declarations of interests, are posted on the NICE website.

Dr Kathryn Abel
Reader and Consultant Psychiatrist, University of Manchester

Professor David Barnett
Professor of Clinical Pharmacology, University of Leicester

Dr David W Black
Director of Public Health, Derbyshire County Primary Care Trust

Dr Brian Buckley
Lay Member

Mark Campbell
Director of Standards and Performance, Bury PCT

Professor Mike Campbell
Professor of Medical Statistics, University of Sheffield

Mr David Chandler
Lay Member

Dr Peter Clark
Consultant Medical Oncologist, Clatterbridge Centre for Oncology

Dr Christine Davey
Senior Researcher, North Yorkshire Alliance R&D Unit

Dr Mike Davies
Consultant Physician, Royal Infirmary, Manchester

Mr Richard Devereaux-Philips
Public Affairs Manager, Medtronic Ltd

Professor Rachel Elliot
Lord Trent Professor of Medicines and Health, University of Nottingham

Dr Peter Jackson
Clinical Pharmacologist, University of Sheffield

Professor Peter Jones
Pro Vice Chancellor for Research & Enterprise, Keele University
Professor of Statistics, Keele University

Mr Henry Marsh
Consultant Neurosurgeon, St George's Hospital London

Professor Jonathan Michaels (Vice Chair)
Professor of Vascular Surgery, University of Sheffield

Dr Eugene Milne
Deputy Medical Director, North East Strategic Health Authority

Professor Simon Mitchell
Consultant Neonatal Paediatrician, St Mary's Hospital, Manchester

Dr Richard Alexander Nakielny
Consultant Radiologist, Royal Hallamshire Hospital, Sheffield

Mrs Ruth Oliver-Williams
Head of Nursing, Quality Improvement Lead Surgical Services, Royal Derby Hospital, Derby

Dr Katherine Payne
Health Economics Research Fellow, University of Manchester

Dr Danielle Preedy
Lay Member

Dr Philip Rutledge
General Practitioner, Consultant in Medicines Management, NHS Lothian

Dr Surinder Sethi
Consultant in Public Health Medicine, North West Specialised Services Commissioning Team

Professor Andrew Stevens (Chair)
Professor of Public Health, Department of Public Health and Epidemiology, University of Birmingham

Dr Matt Stevenson
Technical Director, School of Health and Related Research Technical Assessment Group, University of Sheffield

Dr Cathryn Thomas
Associate Professor and General Practitioner, University of Birmingham

Guideline representatives

The following individuals, representing the Guideline Development Group responsible for developing NICE's guideline related to this topic, were invited to attend the meeting to observe and to contribute as advisers to the Committee.

NICE project team

Each technology appraisal is assigned to a team consisting of 1 or more health technology analysts (who act as technical leads for the appraisal), a technical adviser and a project manager.

Helen Knight
Technical Lead

Janet Robertson
Technical Adviser

Laura Malone
Project Manager

Sources of evidence considered by the Committee

The assessment report for this appraisal was prepared by Southampton Health Technology Assessments Centre, University of Southampton:

Additional evidence for this appraisal was prepared by Southampton Health Technology Assessments Centre, University of Southampton:

The following organisations accepted the invitation to participate in this appraisal as consultees and commentators. They were invited to comment on the draft scope, assessment report and the appraisal consultation document (ACD). Manufacturers or sponsors, professional or specialist and patient or carer groups, and other consultees, were also invited to make written submissions and have the opportunity to appeal against the final appraisal determination.

Manufacturer or sponsor:

Professional or specialist and patient or carer groups:

Other consultees

Commentator organisations (did not provide written evidence and without the right of appeal)

The following individuals were selected from clinical specialist and patient expert nominations from the non-manufacturer or sponsor consultees and commentators. They participated in the Appraisal Committee discussions and provided evidence to inform the Appraisal Committee's deliberations. They gave their expert personal view on topotecan for the treatment of relapsed small-cell lung cancer by attending the initial Committee discussion and/or providing written evidence to the Committee. They were also invited to comment on the ACD.