Evidence-based recommendations on abiraterone (Zytiga) for castration-resistant metastatic prostate cancer in adults who have had previous treatment with a docetaxel-containing regimen.
This guidance has been re-issued after a change to the commercial arrangements in July 2016. This change does not affect abiraterone’s cost effectiveness. Recommendation 1.1, sections 2.3 and 5.4 and the summary of appraisal committee key conclusions table have been updated.
Guidance development process
Is this guidance up to date?
We reviewed the evidence in December 2017. We found nothing new that affects the recommendations in this guidance. We are incorporating the guidance into the update of NICE’s clinical guideline on prostate cancer (CG175).
Next review: This guidance will be reviewed if there is new evidence that is likely to change the recommendations.
The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
Commissioners and/or providers have a responsibility to provide the funding required to enable the guidance to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.