Aflibercept solution for injection for treating wet age‑related macular degeneration

  • Technology appraisal guidance
  • TA294
  • Published: 
Download guidance (PDF)

7 Sources of evidence considered by the Committee

The Evidence Review Group (ERG) report for this appraisal was prepared by Aberdeen HTA Group:

  • Cummins E, Fielding S, Johnston R, Rothnie K, Stewart F, Lois N, Burr J, Brazzelli M. Aflibercept solution for injection for the treatment of wet age‑related macular degeneration. Aberdeen HTA Group, Institute of Applied Health Sciences, University of Aberdeen, 2013

The following organisations accepted the invitation to participate in this appraisal as consultees and commentators. They were invited to comment on the draft scope. Manufacturers or sponsors were also invited to make written submissions. Professional or specialist and patient or carer groups gave their expert views on Aflibercept solution for injection for the first line treatment of wet age‑related macular degeneration (AMD) by providing a written statement to the Committee. Manufacturers or sponsors, professional or specialist and patient or carer groups, and other consultees, have the opportunity to appeal against the final appraisal determination.

Manufacturer or sponsor

  • Bayer

Professional or specialist and patient or carer groups:

  • Macular Society

  • Royal National Institute of Blind People (RNIB)

  • Royal College of Nursing

  • Royal College of Ophthalmologists

  • Royal College of Pathologists

Other consultees:

  • Department of Health

  • Bristol, North Somerset and South Gloucestershire (PCT Cluster)

  • Welsh Government

Commentator organisations (did not provide written evidence and without the right of appeal):

  • Commissioning Support Appraisals Service

  • Department of Health, Social Services and Public Safety for Northern Ireland

  • Healthcare Improvement Scotland

  • Moorfields Pharmaceuticals

  • Novartis Pharmaceuticals

  • Aberdeen HTA Group

  • National Institute for Health Research Health Technology Assessment Programme

The following individuals were selected from clinical specialist and patient expert nominations from the consultees and commentators. They gave their expert personal view on aflibercept by providing oral evidence to the Committee.

  • Ian Pearce, Consultant Ophthalmologist, nominated by RNIB – clinical specialist

  • Robert Johnson, Consultant Ophthalmologist, nominated by Bayer – clinical specialist

  • Sobha Sivaprasad, Consultant Ophthalmologist, nominated by The Royal College of Ophthalmologists ‑ clinical specialist

  • Cathy Yelf, nominated by Macular Society ‑ patient expert

  • Clara Eaglan, nominated by RNIB ‑ patient expert

Representatives from the following manufacturer/sponsor attended Committee meetings. They contributed only when asked by the Committee chair to clarify specific issues and comment on factual accuracy.

  • Bayer

ISBN 978-1-4731-0234-7