Documents A list of downloadable documents created during development. Final appraisal determination Final appraisal determination Final appraisal determination document PDF 259.88 KB 17 September 2018 Committee papers PDF 22.05 MB 17 September 2018 Public committee slides - clinical PDF 565.41 KB 17 September 2018 Public committee slides - cost effectiveness PDF 648 KB 17 September 2018 Invitation to participate Final scope PDF 225.02 KB 09 February 2018 Final matrix PDF 260.6 KB 09 February 2018 NICE's response to comments on the draft scope and provisional matrix PDF 334.54 KB 09 February 2018 Consultation on suggested remit, draft scope and provisional matrix of consultees and commentators Consultation on suggested remit, draft scope and provisional matrix of consultees and commentators Draft scope post referral PDF 316.64 KB 09 October 2017 Draft matrix post referral PDF 259.79 KB 09 October 2017