2 Information about nusinersen
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Marketing authorisation indication |
Nusinersen (Spinraza, Biogen Idec) has a marketing authorisation for 'the treatment of 5q spinal muscular atrophy'. |
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Dosage in the marketing authorisation |
12 mg, by intrathecal infusion, on days 0, 14, 28 and 63, then every 4 months. |
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Price |
The list price is £75,000 per vial (excluding VAT; BNF, accessed June 2018). At the list price, the total annual treatment cost is £450,000 for the first year and £225,000 for subsequent years. Over 5 years, the treatment costs per person would be £1.35 million. The company has a commercial arrangement. This makes nusinersen available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount. |