NICE is unable to make a recommendation about the use in the NHS of eculizumab for treating refractory myasthenia gravis because Alexion Pharma UK did not provide an evidence submission. The company has confirmed that it does not intend to make a submission for the appraisal because the technology will not be launched in the UK for this indication.
If NHS organisations wish to consider eculizumab for treating refractory myasthenia gravis, they should follow the advice on rational local decision making in the NHS Constitution for England and the NHS Commissioning Board and Clinical Commissioning Groups (Responsibilities and Standing Rules) Regulations 2012. This outlines the approach that should be taken when there is no NICE guidance.
NICE will review the position if the company decides that it wants to make an evidence submission.