Naldemedine for treating opioid-induced constipation

2.1 Naldemedine (Rizmoic, Shionogi) has a marketing authorisation in the UK for 'the treatment of opioid-induced constipation in adult patients who have previously been treated with a laxative'.

2.2 The dosage schedule is available in the summary of product characteristics.

2.3 The list price of a 28-tablet pack of naldemedine is £41.72 (excluding VAT; BNF online, accessed March 2020). The cost of a course of treatment depends on the duration of opioid-induced constipation needing treatment. Costs may vary in different settings because of negotiated procurement discounts.