2 Information about encorafenib plus cetuximab

Marketing authorisation indication

2.1 Encorafenib (Braftovi; Pierre Fabre Ltd) has a marketing authorisation in combination with cetuximab (Erbitux; Merck Serono Ltd) 'for the treatment of adult patients with metastatic colorectal cancer (CRC) with a BRAF V600E mutation, who have received prior systemic therapy'. Because the marketing authorisation did not include triple therapy (encorafenib plus binimetinib and cetuximab), this appraisal only considers dual therapy.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics.


2.3 The list price of encorafenib 75 mg is £1,400 for 42 capsules (excluding VAT; BNF online accessed October 2020).

The list price of cetuximab 5 mg per millilitre solution for infusion is £890.50 for 100 millilitres (excluding VAT; BNF online accessed October 2020).

The companies have commercial arrangements for each of the drugs. These make encorafenib and cetuximab available to the NHS with discounts. The size of the discounts are commercial in confidence. It is the companies' responsibility to let relevant NHS organisations know details of the discounts.

  • National Institute for Health and Care Excellence (NICE)