Information for the public

Andexanet alfa (Ondexxya) is a possible treatment for reversing anticoagulation from apixaban or rivaroxaban in adults with life-threatening or uncontrolled bleeding.

It is available on the NHS if the bleed is in the gastrointestinal tract.

If the bleed is in the skull (intracranial haemorrhage), andexanet alfa is only available for people taking part in an ongoing research study (randomised trial) mandated by the regulator.

Is this treatment right for me?

Your healthcare professionals should give you clear information, talk with you about your options and listen carefully to your views and concerns. Your family can be involved too, if you wish. Read more about making decisions about your care.

Questions to think about

  • How well does it work compared with other treatments?
  • What are the risks or side effects? How likely are they?
  • How will the treatment affect my day‑to‑day life?
  • What happens if the treatment does not work?
  • What happens if I do not want to have treatment? Are there other treatments available?

Information and support

These organisations can give you advice and support:

You can also get support from your local Healthwatch.

NICE is not responsible for the quality or accuracy of any information or advice provided by these organisations.

ISBN: 978-1-4731-4084-4

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