2 Information about pembrolizumab

Marketing authorisation indication

2.1 Pembrolizumab (Keytruda; Merck Sharp and Dohme) has a marketing authorisation as monotherapy 'for the first-line treatment of metastatic microsatellite instability-high or mismatch repair deficient colorectal cancer in adults'.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics.


2.3 The list price of pembrolizumab is £2,630 per 100-mg vial (excluding VAT; BNF online, accessed March 2021). The cost of a single administration is £5,260. This represents 3 weeks of treatment.

2.4 The company has a commercial arrangement. This makes pembrolizumab available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.

  • National Institute for Health and Care Excellence (NICE)