Information for the public

Pembrolizumab (Keytruda) with platinum- and fluoropyrimidine-based chemotherapy is available on the NHS as a possible treatment for carcinoma of the oesophagus or HER2‑negative gastro-oesophageal junction adenocarcinoma in adults. It is only available if the person has not had treatment before and their cancer:

  • is locally advanced and can’t be removed by surgery (unresectable) or
  • has spread to other parts of the body (metastatic) and
  • expresses a type of protein called PD‑L1 with a score of 10 or more on a scale called the combined positive score, which measures PD‑L1 expression.

Is this treatment right for me?

Your healthcare professionals should give you clear information, talk with you about your options and listen carefully to your views and concerns. Your family can be involved too, if you wish. Read more about making decisions about your care.

Questions to think about

  • How well does it work compared with other treatments?
  • What are the risks or side effects? How likely are they?
  • How will the treatment affect my day-to-day life?
  • What happens if the treatment does not work?
  • What happens if I do not want to have treatment? Are there other treatments available?

Information and support

The NHS website may be a good place to find out more.

These organisations can give you advice and support:

You can also get support from your local Healthwatch.

NICE is not responsible for the quality or accuracy of any information or advice provided by these organisations.

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