5 Recommendations for further research

5.1 Current trials involving peginterferon alfa for people with moderate or severe chronic CHC are reported in Appendix 11 of the Assessment Report. These consist of one trial of a triple therapy, five trials of combination therapy, two of monotherapy, five of co-infected populations and one to assess the long-term SVR in children. Trials for people with mild chronic CHC are also near completion. In addition, a randomised controlled trial of combination therapy involving pegylated interferon alfa-2a versus alfa-2b is being planned.

5.2 A well-constructed trial of peginterferon alfa combination therapy versus other therapies involving interferon alfa is needed in children with chronic CHC.