Information for the public

Trastuzumab deruxtecan (Enhertu) is available with managed access. It is a possible treatment for HER2‑positive breast cancer in adults if:

  • their cancer cannot be removed by surgery (unresectable), or
  • their cancer has spread to other parts of the body (metastatic), and
  • they have had 1 or more anti-HER2 treatments.

More evidence on trastuzumab deruxtecan is being collected. It will be available through managed access until NICE is able to evaluate the new evidence following the data collection period.

If you are not eligible for trastuzumab deruxtecan but are already having it, you should be able to continue until you and your doctor decide when best to stop.

Is this treatment right for me?

Your healthcare professionals should give you clear information, talk with you about your options and listen carefully to your views and concerns. Your family can be involved too, if you wish. See our webpage on making decisions about your care.

Questions to think about

  • How well does it work compared with other treatments?
  • What are the risks or side effects? How likely are they?
  • How will the treatment affect my day-to-day life?
  • What happens if the treatment does not work?
  • What happens if I do not want to have treatment? Are there other treatments available?

Information and support

The NHS webpage on breast cancer may be a good place to find out more.

These organisations can give you advice and support:

You can also get support from your local Healthwatch.

NICE is not responsible for the quality or accuracy of any information or advice provided by these organisations.

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