NICE is unable to make a recommendation about the use in the NHS of dupilumab for treating eosinophilic oesophagitis in people 12 years and over. This is because Sanofi has confirmed that it does not intend to make an evidence submission for the appraisal. Sanofi considers that there is currently unlikely to be enough evidence that the technology is a cost-effective use of NHS resources for this population.


If NHS organisations wish to consider dupilumab for this indication, they should follow the advice on rational local decision making in the NHS Constitution for England and the NHS Commissioning Board and Clinical Commissioning Groups (Responsibilities and Standing Rules) Regulations 2012. This outlines the approach that should be taken when there is no NICE guidance.

NICE will review the position if the company decides that it wants to make an evidence submission.

ISBN: 978-1-4731-5610-4

  • National Institute for Health and Care Excellence (NICE)