5 Recommendations for further research

5 Recommendations for further research

5.1 There is considerable concern about viral resistance in the long-term treatment of chronic hepatitis B. Further research is needed on the role of combination therapy with antiviral drugs in reducing the development of resistance to treatment. There is at least one ongoing study comparing lamivudine alone with lamivudine in combination with adefovir dipivoxil in treatment-naive people with chronic hepatitis B.