• Skip to content
  • Accessibility help
Skip to content
Sign in
  • Guidance
  • Skip Standards and indicators submenu

    Quality standards

    Our quality standards set out priority areas for quality improvement. They highlight areas with identified variation in current practice.

    View our quality standards

    • How to use our quality standards
    • The timeline for developing quality standards
    • Help us develop quality standards
    • Selecting and prioritising quality standards topics
    • About quality standards

    Indicators

    Our indicators measure outcomes that reflect the quality of care, or processes linked by evidence to improved outcomes.

    View list of indicators

    • Learn about the committee that develops indicators
    • About indicators
  • Skip Life sciences submenu

    Life Sciences

    We offer tailored support to industry during product development. Our expertise can help you build the evidence needed to achieve market access.

    View life sciences

    Get support from NICE

    NICE Advice service

    Trusted, unrivalled expertise.

    Make an enquiry

    Contact us to discuss your requirements.

    Innovative Licensing and Access Pathway (ILAP)

    Streamlining patient access to safe, financially sustainable and innovative medicines.

    Learn how we evaluate technologies

    Health technology evaluation and topic selection manuals

    Updated manuals for methods, processes and topic selection.

    Digital health technologies

    Accelerating our efforts to deliver innovation to the health and care system.

    Evidence standards framework

    Using the best available evidence to develop recommendations that guide decisions in health, public health and social care.

    Our guidance programmes

    Ensuring new technologies are clinically effective and offer economic value.

    Register your product

    Non-pharmaceutical

    NHS Innovation Service is a clear and simple point of entry for health technologies to access support and national evaluation programmes.

    Pharmaceutical

    UK PharmaScan is a database of new medicines, indications and formulations in the pharmaceutical pipeline.

    Find published and proposed evaluations

    Diagnostics

    Guidance on measurements and tests used to evaluate a patient's condition.

    Medical technologies

    Guidance on medical technologies put forward to NICE by manufacturers.

    Technology appraisals

    Guidance on new and existing medicines and treatments in the NHS.

    Highly specialised technologies

    Guidance on the use of highly specialised medicines and treatments.

  • British National Formulary (BNF)
  • British National Formulary for Children (BNFC)
  • Clinical Knowledge Summaries (CKS)
  • Skip About submenu

    About

    NICE helps practitioners and commissioners get the best care to patients, fast, while ensuring value for the taxpayer.

    Explore about

    Our programmes

    Learn about the information we produce.

    • Guidance
    • Advice
    • Quality standards
    • Indicators
    • Digital health
    • Topic selection

    Get involved

    • Understand how decisions are made:

      Attend a committee meeting
    • Comment on draft guidance:

      Guidance in consultation
    • Be part of a guidance committee:

      Join a committee
    • Help develop our products:

      Register as a stakeholder
    • Putting you at the heart of our work:

      Public involvement

    What we do

    • Social care
    • Life sciences
    • NICE international
    • Patient safety
    • Shared decision making
    • View all What we do

    Into practice

    • Social care quick guides
    • Measuring the use of NICE guidance
    • Resource planner
    • View all Into practice

    Who we are

    • The board
    • The NICE strategy 2021 to 2026
    • Corporate publications
    • View all Who we are

    • Contact us
    • Jobs

My account

  • Consultation responses
  • Sign in

You are here:

  1. Home

Developing NICE guidelines: the manual

  • NICE process and methods
  • Reference number: PMG20
  • Published:  31 October 2014
  • Last updated:  29 May 2024
  • Process
  • Tools and resources
Download (PDF)
  • Overview
  • 1 Introduction
  • 2 The scope
  • 3 Decision-making committees
  • 4 Developing review questions and planning the evidence review
  • 5 Identifying the evidence: literature searching and evidence submission
  • 6 Reviewing evidence
  • 7 Incorporating economic evaluation
  • 8 Linking to other guidance
  • 9 Interpreting the evidence and writing the guideline
  • 10 The validation process for draft guidelines, and dealing with stakeholder comments
  • 11 Finalising and publishing the guideline recommendations
  • 12 Support for putting the guideline recommendations into practice
  • 13 Ensuring that published guidelines are current and accurate
  • 14 Updating guideline recommendations
  • 15 Appendices
  • Glossary
  • Update information

15 Appendices

Appendices A to P can be found via tools and resources.

  • Appendix A: Service delivery – developing review questions, evidence reviews and synthesis

  • Appendix B: Approaches to additional consultation and commissioned primary research

  • Appendix C: Key roles and responsibilities of committee members

  • Appendix D: Guideline committee Terms of Reference and Standing Orders

  • Appendix E: Code of conduct for committee members

  • Appendix F: Suggested sources for scoping

  • Appendix G: Sources for evidence reviews

  • Appendix H: Appraisal checklists, evidence tables, GRADE and economic profiles

  • Appendix I: Review protocol template

  • Appendix J: Call for evidence and expert witnesses

  • Appendix K: Network meta-analysis reporting standards

  • Appendix L: Process and methods for guidelines developed in response to health and social care emergencies

  • Appendix M: Interim principles for methods and processes for supporting digital living guideline recommendations

  • Appendix N: Surveillance decision framework and multi-criteria decision framework for deciding whether to develop or update recommendations and which methods to use

  • Appendix O: Surveillance - interim principles for monitoring approaches of guideline recommendations

  • Appendix P: Updating guideline recommendations


Next page Glossary Previous page 14 Updating guideline recommendations
Back to top
  • Guidance
  • Standards and indicators
  • Life sciences
  • British National Formulary (BNF)
  • British National Formulary for Children (BNFC)
  • Clinical Knowledge Summaries (CKS)
  • Knowledge resources
  • About NICE
  • Into practice
  • Get involved with NICE
  • Jobs
  • News
  • Newsletters and alerts
  • Contact us
  • Leave feedback
  • Reusing our content
  • NICE UK Open Content Licence
  • Syndicate our content
  • Events
  • Facebook
  • X
  • YouTube
  • LinkedIn
  • Accessibility
  • Freedom of information
  • Glossary
  • Terms and conditions
  • Privacy notice
  • Cookies

© NICE 2025. All rights reserved. Subject to Notice of rights.