2 Key drivers of the cost effectiveness of the comparators

2 Key drivers of the cost effectiveness of the comparators

2.1 Clinical outcomes and measures

To inform the appraisal committee's evaluation of whether the technology provides similar or greater overall health benefits than the comparator(s) specified in the NICE scope and relevant to the decision problem, it is important that the evidence base for the technology includes the same outcomes and the same measurement scales that were used in the NICE technology appraisal(s) of these comparator(s). The purpose of section 2.1 of the submission is to identify the relevant outcome measures and highlight which ones were important in estimating the cost effectiveness of the comparator(s), that is, which clinical outcomes the model was sensitive to. A suggested format for presenting this information is provided below.

Table X Clinical outcomes and measures appraised in published NICE guidance for the comparator(s)

Outcome

Measurement scale

Used in cost-effectiveness model?

Impact on ICER*

Committee's preferred assumptions

Uncertainties

NICE TAXXX

NICE TAXXX

[Add more rows as needed]

*Was the ICER sensitive to changes in this outcome? How did changes in the outcome affect the ICER (increase or decrease)?

Abbreviations: TA; technology appraisal, ICER; incremental cost-effectiveness ratio

2.2 Resource use assumptions

The purpose of section 2.2 of the submission is to identify the cost data and sources that were considered appropriate in the published NICE guidance for the comparator(s) specified in the NICE scope and relevant to the decision problem. This should inform the selection of data and sources for the cost-comparison analysis.

2.2.1 Summarise the committee's preferred assumptions about resource use and the associated costs from the NICE technology appraisal(s) of the comparator(s) relevant to the decision problem, for example, the frequency of monitoring visits. Describe any uncertainties in the assumptions and estimates used in the previous NICE appraisal(s).