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1 Recommendations

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2 Information about tucatinib

Marketing authorisation indication

2.1 Tucatinib (TUKYSA, Seagen Inc.) has a marketing authorisation for use 'in combination with trastuzumab and capecitabine for the treatment of adult patients with HER2-positive locally advanced or metastatic breast cancer who have received at least two prior anti-HER2 treatment regimens'.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics.

Price

2.3 The company's list price is £5,636.84 per pack of 84, 150 mg film-coated tablets (company's submission). The average cost of a course of combination treatment at list prices is £7,016.91 for the loading dose and £6,677.14 for the following cycles.

The company has a commercial arrangement, which would have applied if the technology had been recommended.