Evidence: economic issues

Evidence: economic issues

Cost effectiveness

No cost-effectiveness studies were identified.


Metformin is available as standard-release and modified-release tablets. Modified-release tablets are sometimes prescribed in an attempt to reduce the gastrointestinal adverse effects of metformin.

Drug and usual dosage a

Annual cost b

Metformin 500 mg 3 times a day


Metformin 1000 mg twice a day


Metformin modified-release 750 mg twice a day


Co-cyprindiol 1 daily for 21 days each month


a The dosages shown are taken from the relevant summary of product characteristics, but do not represent the full range that can be used nor do they imply therapeutic equivalence.

b Costs taken from Drug Tariff January 2013, based on 13×28-day months per year.

Current drug usage

It is not possible to determine the indications for which metformin is prescribed, therefore no information on prescribing rates of metformin for PCOS is available.