The PressureWire Aeris and PressureWire Certus (with Agile Tip) fractional flow reserve (FFR) devices are intended to measure the functional stenosis in a coronary artery, to help with treatment decisions in coronary artery disease and evaluate effectiveness of treatment. The PressureWire FFR devices have been compared against coronary angiography in clinical studies.
Evidence from 3 systematic reviews, 4 randomised controlled trials and 1 large cohort study indicates the PressureWire devices can be effective as adjuncts to coronary angiography to identify functionally significant stenosis, to help determine the best treatment for people with coronary artery disease.
Four economic analyses evaluated FFR guided-strategies using the PressureWire FFR devices. However, they did not directly address whether using the devices would be cost effective in the NHS.