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Olaparib for previously treated BRCA-mutation positive hormone-relapsed metastatic prostate cancer

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2 Information about olaparib

Marketing authorisation indication

2.1 Olaparib (Lynparza, AstraZeneca) is indicated 'as monotherapy for the treatment of adult patients with metastatic castration-resistant prostate cancer and BRCA1/2-mutations (germline and/or somatic) who have progressed following prior therapy that included a new hormonal agent'.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics.

Price

2.3 The price for olaparib is £2,317.50 per pack of 56 tablets, each containing 100 mg or 150 mg of the active ingredient (excluding VAT; BNF online, February 2021). The company has a commercial arrangement. This makes olaparib available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.