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2 Information about pembrolizumab plus carboplatin and paclitaxel or nab-paclitaxel

Marketing authorisation indication

2.1 Pembrolizumab (Keytruda, Merck Sharp & Dohme) plus carboplatin and paclitaxel or nab‑paclitaxel is indicated for 'the first‑line treatment of metastatic squamous non‑small-cell lung carcinoma in adults'.

2.2 Nab-paclitaxel is not commissioned by NHS England (see NICE technology appraisal 362 – terminated appraisal) and is therefore not considered as part of the appraisal recommendation.

Price

2.4 Pembrolizumab solution for infusion costs £2,630 per 100‑mg vial (excluding VAT; BNF online, accessed August 2021).

2.5 The company has a commercial arrangement. This makes pembrolizumab available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.