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    Literature search strategy

    Databases

    Date searched

    Version/files

    Cochrane Database of Systematic Reviews – CDSR (Cochrane Library)

    15/06/2021

    Issue 6 of 12, June 2021

    Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library)

    15/06/2021

    Issue 6 of 12, June 2021

    International HTA database (INAHTA)

    15/06/2021

    -

    MEDLINE (Ovid)

    15/06/2021

    1946 to June 14, 2021

    MEDLINE In-Process (Ovid)

    15/06/2021

    1946 to June 14, 2021

    MEDLINE Epubs ahead of print (Ovid)

    15/06/2021

    June 14, 2021

    EMBASE (Ovid)

    15/06/2021

    1974 to 2021 June 14

    The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.

    Literature search strategy

    Number

    Search term

    1

    Marfan Syndrome/

    2

    (Marfan* adj4 syndrom*).tw.

    3

    MFS.tw.

    4

    Connective Tissue Diseases/

    5

    (connect* tissue* adj4 (disease* or disord*)).tw.

    6

    Aneurysm, Dissecting/

    7

    Aortic Aneurysm/

    8

    ((aortic* or aorta*) adj4 (dissect* or dilat* or ascend* or aneurysm* or aneurism* or tear* or expand* or enlarge* or rupture* or regurgitat* or cut*or wide*)).tw.

    9

    or/1-8

    10

    PEARS.tw.

    11

    personalise* external* aortic* root support*.tw.

    12

    ((bespoke* or custom* or tailor* or personal* or exact* or individual* or modif* or adapt*) adj4 (support* or graft*)).tw.

    13

    (aort* adj4 (support* or polymer* or mesh*)).tw.

    14

    Computer-Aided Design/

    15

    (comput* adj4 (assist* or aid*)).tw.

    16

    (digital* adj4 imag*).tw.

    17

    (rapid adj4 prototyp*).tw.

    18

    or/10-17

    19

    9 and 18

    20

    exovasc*.tw.

    21

    exostent.tw.

    22

    20 or 21

    23

    19 or 21

    24

    animals/ not humans/

    25

    23 not 24