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    The content on this page is not current guidance and is only for the purposes of the consultation process.

    Methods

    NICE identified studies and reviews relevant to intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure caused by high spinal cord injuries from the medical literature. The following databases were searched between the date they started to 20 July 2022: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.

    The following inclusion criteria were applied to the abstracts identified by the literature search.

    • Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature.

    • Patients with ventilator-dependent chronic respiratory failure caused by high spinal cord injuries.

    • Intervention or test: intramuscular diaphragm stimulation.

    • Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.

    If selection criteria could not be determined from the abstracts the full paper was retrieved.

    Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.

    Find out more about how NICE selects the evidence for the committee.

    Table 4 literature search strategy

    Databases

    Date searched

    Version/files

    MEDLINE (Ovid)

    20/07/2022

    1946 to July 19, 2022

    MEDLINE In-Process (Ovid)

    20/07/2022

    1946 to July 19, 2022

    MEDLINE Epubs ahead of print (Ovid)

    20/07/2022

    July 19, 2022

    EMBASE (Ovid)

    20/07/2022

    1974 to 2022 July 19

    EMBASE Conference (Ovid)

    20/07/2022

    1974 to 2022 July 19

    Cochrane Database of Systematic Reviews – CDSR (Cochrane Library)

    20/07/2022

    Issue 7 of 12, July 2022

    Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library)

    20/07/2022

    Issue 7 of 12, July 2022

    International HTA database (INAHTA)

    20/07/2022

    n/a

    The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.

    MEDLINE search strategy

    1 (diaphragm* adj4 (stimulat* or technique* or system*)).tw.

    2 (diaphragm* adj4 pac*).tw.

    3 IDS.tw.

    4 DPS.tw

    5 (respirat* adj4 stimulat* adj4 system*).tw.

    6 or/1-5

    7 diaphragm/

    8 diaphrag*.tw.

    9 Respiration/

    10 breathing/

    11 respirat*.tw.

    12 or/7-11

    13 Electric Stimulation Therapy/

    14 electrotherapy/

    15 (electric* adj4 stimulat* adj4 therap*).tw.

    16 electrotherap*.tw.

    17 or/13-16

    18 12 and 17

    19 6 or 18

    20 respiratory failure/

    21 Respiratory Paralysis/

    22 Respiratory Insufficiency/

    23 ((Respirator* or ventilat* or diaphrag*) adj4 (insufficien* or weakness* or deficienc* or paralysis* or fail*)).tw.

    24 spinal cord disease/

    25 (spin* adj4 cord* adj4 injur*).tw.

    26 amyotrophic lateral sclerosis/

    27 (Amyotrophic* adj4 Latera* adj4 Sclero*).tw.

    28 ALS.tw.

    29 (gehrig* adj4 diseas*).tw.

    30 motor neuron disease/

    31 (motor* adj4 neuron* adj4 diseas*).tw.

    32 exp multiple sclerosis/

    33 (multipl* adj4 scleros*).tw.

    34 MS.tw.

    35 quadriplegia/

    36 paraplegia/

    37 (Quadripleg* or parapleg* or tetrapleg*).tw.

    38 or/20-37

    39 19 and 38

    40 Animals/ not Humans/

    41 39 not 40