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    The content on this page is not current guidance and is only for the purposes of the consultation process.

    Interventional procedure overview of irreversible electroporation for treating prostate cancer

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    Additional information considered by IPAC

    Professional experts' opinions

    Expert advice was sought from consultants who have been nominated or ratified by their professional Society or Royal College. The advice received is their individual opinion and is not intended to represent the view of the society. The advice provided by professional experts, in the form of the completed questionnaires, is normally published in full on the NICE website during public consultation, except in circumstances but not limited to, when comments are considered voluminous, or publication would be unlawful or inappropriate. Three professional expert questionnaires for irreversible electroporation for treating prostate cancer were submitted, two of which can be found on the NICE website.

    Patient organisation submissions

    One patient organisation submission for irreversible electroporation for treating prostate cancer was received and can be found on the NICE website.

    Patient commentators' opinions

    NICE's Public Involvement Programme sent questionnaires to NHS trusts for distribution to patients who had the procedure. NICE received 101 completed questionnaires.

    The patient commentators' views on the procedure were consistent with the published evidence and the opinions of the professional experts. See the patient commentary summary for more information.

    Company engagement

    A structured information request was sent to 1 company who manufacture a potentially relevant device for use in this procedure. NICE received 0 completed submissions.

    Issues for consideration by IPAC

    Ongoing trials and registries:

    • Multi-Centre Randomised Clinical Two Arm Intervention Study Evaluating Irreversible Electroporation for the Ablation of Localised Prostate Cancer (NCT01835977); RCT; n=106; study completion date Jan 2025 [active, not recruiting]

    • Registry of Irreversible Electroporation for the Ablation of Prostate Cancer with Use of Nanoknife Device (NCT02255890); Cohort study; the Netherlands; n=361; study completion date April 2025 [active, not recruiting]

    • A Prospective, Single-centre, Randomised Controlled Trial Comparing the Functional and Oncological Outcomes of High-frequency Irreversible Electroporation and Laparoscopic Radical Prostatectomy in Men With Localised Prostate Cancer (NCT04278261); RCT; n=216; study completion date September 2026 [not yet recruiting]