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2 Information about pembrolizumab

Marketing authorisation indication

2.1 Pembrolizumab (KEYTRUDA, MSD) as 'monotherapy is indicated for the adjuvant treatment of adults with renal cell carcinoma at increased risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions'.

Price

2.3 The cost of a 100 mg/4 ml vial of pembrolizumab is £2,630 (excluding VAT; BNF online accessed April 2022). The cost of a 12‑month course (17 cycles) of treatment is £89,420.

2.4 The company has a commercial arrangement. This makes pembrolizumab available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.