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    Table 1 Abbreviations

    Abbreviation

    Definition

    ABPM

    Ambulatory 24 h blood pressure monitoring

    AE

    Adverse event

    ALT

    Alanine aminotransferase

    ASCVD

    Atherosclerotic cardiovascular disease

    AST

    Aspartate aminotransferase

    BMI

    Body mass index

    DIAL

    Diabetes lifetime-perspective prediction

    DMR

    Duodenal mucosal resurfacing

    DTSQ

    Diabetes Treatment Satisfaction Questionnaire

    FPG

    Fasting plasma glucose

    FPI

    Fasting plasma insulin

    GI

    Gastrointestinal

    GLP-1/GLP-1RA

    Glucagon-like peptide-1 (receptor agonists)

    HDL

    High-density lipoprotein

    HOMA-IR

    Homeostatic Model Assessment Index for Insulin Resistance

    IQR

    Interquartile range

    LDL

    Low-density lipoprotein

    LS-DMR

    Long segment ablation (about 9.3 cm treated) for duodenal mucosal resurfacing

    MAP

    Mean arterial pressure

    mITT

    Modified intention-to-treat

    PDFF

    Proton density fat function

    PP

    Per protocol

    RCT

    Randomised controlled trial

    SAE

    Serious adverse event

    SAT

    Subcutaneous adipose tissue

    SD

    Standard deviation

    SS-DMR

    Short segment ablation (about 3.4 cm treated) for duodenal mucosal resurfacing

    T2D

    Type 2 diabetes (mellitus)

    VAT

    Visceral adipose tissue