Interventional procedure overview of endoscopic duodenal mucosal resurfacing for insulin resistance in type 2 diabetes
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Other relevant studies
Other potentially relevant studies to the IP overview that were not included in the main evidence summary (tables 2 and 3) are listed below.
Article | Number of patients and follow up | Direction of conclusions | Reason study was not included in main evidence summary |
|---|---|---|---|
van Baar AC, Beuers U, Wong K et al. (2019) Endoscopic duodenal mucosal resurfacing improves glycaemic and hepatic indices in type 2 diabetes: 6-month multicentre results. JHEP Reports, 1(6), 429-437 | N=94 6 months follow up | Lower mean HbA1c 6 months after DMR (7.9 ± 0.2%) compared with baseline (9.0 ± 0.2%, p<0.001). Lower FPG, AST and ALT at 6 months. | Reviews Rajagopalan (2016) which is included in Table 2 and van Baar (2020) which is superseded by the 2-year follow up, van Baar (2022). |
van Baar AC, Holleman F, Crenier L et al. (2020) Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study. Gut, 69(2), 295-303 | N=46 1 year follow up | Lower mean HbA1c at 24 weeks after DMR and sustained to 12 months. FPG, HOMA-IR and weight improved after DMR. | Superseded by the 2-year follow up, van Baar (2022). |
Boškoski I, Orlandini B, Gallo C et al. (2020) Metabolic endoscopy by duodenal mucosal resurfacing: expert review with critical appraisal of the current technique and results. Expert Review of Gastroenterology & Hepatology, 14(5), 375-381 | N=92 | DMR has shown promising preliminary results in terms of efficacy and safety among the arsenal of treatments of T2D. | Literature review with expert commentary of 2 single case reports, Rajagopalan (2016) which is included in Table 2 and van Baar (2020) which is superseded by the 2-year follow up, van Baar (2022). |
de Oliveira GHP, de Moura DTH, Funari MP et al. (2021) Metabolic effects of endoscopic duodenal mucosal resurfacing: a systematic review and meta-analysis. Obesity Surgery, 31, 1304-1312 | N=127 | Estimated pooled improvements from baseline in HbA1c at 3 and 6 months after DMR. DMR improved FPG, ALT and liver fat, and likely led to reduced weight for patients. | Reviews 2 abstracts, Rajagopalan (2016) which is included in Table 2 and van Baar (2020) which is superseded by the 2-year follow up, van Baar (2022). |
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