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2 Information about pembrolizumab

Marketing authorisation indication

2.1

Pembrolizumab (Keytruda, Merck Sharp and Dohme) 'in combination with fluoropyrimidine and platinum-containing chemotherapy, is indicated for the first-line treatment of locally advanced unresectable or metastatic HER2‑negative gastric or gastro-oesophageal junction adenocarcinoma in adults whose tumours express PD‑L1 with a CPS ≥1'.

Price

2.3

The list price of pembrolizumab is £2,630 for a 100 mg per 4 ml concentrate for solution for infusion vial (excluding VAT; BNF online accessed February 2024)

2.4

The company has a commercial arrangement. This makes pembrolizumab available to the NHS with a discount and it would have also applied to this indication if the technology had been recommended. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.